1bjt: Difference between revisions

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[[Image:1bjt.~~gif~~|left|200px]]

[[Image:1bjt.png|left|200px]]

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~~'''~~TOPOISOMERASE II RESIDUES 409-1201~~'''~~

===TOPOISOMERASE II RESIDUES 409-1201===

~~==Overview==~~

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~~Type II DNA topoisomerases mediate the passage of one DNA duplex through a transient break in another~~, ~~an event essential for chromosome segregation and cell viability. The active sites of~~ the ~~type II topoisomerase dimer associate covalently with~~ the ~~DNA break-points and must separate by~~ at ~~least the width of the second DNA duplex to accommodate transport~~. ~~A new structure of the Saccharomyces cerevisiae topoisomerase II DNA-binding and cleavage core suggests that in addition to conformational changes in~~ the ~~DNA-opening platform, a dramatic reorganization of accessory domains may occur during catalysis~~. ~~These conformational differences have implications for both the DNA~~-~~breaking and duplex~~-transport events in the topo II reaction mechanism, suggest a mechanism by which two distinct drug-resistance loci interact, and illustrate the scope of structural changes in the cycling of molecular machines.

The line below this paragraph, {{ABSTRACT_PUBMED_10201398}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10201398 is the PubMed ID number.

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==About this Structure==

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[[Category: Quaternary change]]

[[Category: Topoisomerase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 11~~:36:23 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:16:41 2008''

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-[[Image:1bjt.gif|left|200px]]
+{{Seed}}
+[[Image:1bjt.png|left|200px]]
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 {{STRUCTURE_1bjt|  PDB=1bjt  |  SCENE=  }}
-'''TOPOISOMERASE II RESIDUES 409-1201'''
+===TOPOISOMERASE II RESIDUES 409-1201===
-==Overview==
+<!--
-Type II DNA topoisomerases mediate the passage of one DNA duplex through a transient break in another, an event essential for chromosome segregation and cell viability. The active sites of the type II topoisomerase dimer associate covalently with the DNA break-points and must separate by at least the width of the second DNA duplex to accommodate transport. A new structure of the Saccharomyces cerevisiae topoisomerase II DNA-binding and cleavage core suggests that in addition to conformational changes in the DNA-opening platform, a dramatic reorganization of accessory domains may occur during catalysis. These conformational differences have implications for both the DNA-breaking and duplex-transport events in the topo II reaction mechanism, suggest a mechanism by which two distinct drug-resistance loci interact, and illustrate the scope of structural changes in the cycling of molecular machines.
+The line below this paragraph, {{ABSTRACT_PUBMED_10201398}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10201398 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10201398}}
 ==About this Structure==
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 [[Category: Quaternary change]]
 [[Category: Topoisomerase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:36:23 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:16:41 2008''