User:Andre Wu Le Chun/Sandbox 1: Difference between revisions
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== Interaction with angiotensin-converting enzime 2 == | == Interaction with angiotensin-converting enzime 2 == | ||
The interaction between the 2019-nCov and the host cell begins with the recognition of the ACE2, a dimeric protein. Then, the S1 subunit moves, modifying the protein's conformation in way that receptor-binding domain becomes available to connect itself to the peptidase domain of the receptor. At that | The interaction between the 2019-nCov and the host cell begins with the recognition of the ACE2, a dimeric protein. Then, the S1 subunit moves, modifying the protein's conformation in way that receptor-binding domain becomes available to connect itself to the peptidase domain of the receptor. At that moment, the spike protein is found in a "up" conformation. Due to the existence of four amino acids in between the 680 and 685 positions, a furin cleavage site is featured in the protein. Once this site is cleaved by host's furins, a later cleavage at S2' by a serine protease, TMPRSS2, happens in order to allow the activation of the fusion mechanism. Lastly, the spike protein makes a high affinity bond with ACE2 at the order of 15nM and a complex of spike protein and ACE2, as shown in figure 3, is formed. | ||
[[Image:Spike.jpg|500px|]] | [[Image:Spike.jpg|500px|]] | ||
