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[[Image:1bkb.jpg|left|200px]]
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{{STRUCTURE_1bkb|  PDB=1bkb  |  SCENE=  }}  
{{STRUCTURE_1bkb|  PDB=1bkb  |  SCENE=  }}  


'''INITIATION FACTOR 5A FROM ARCHEBACTERIUM PYROBACULUM AEROPHILUM'''
===INITIATION FACTOR 5A FROM ARCHEBACTERIUM PYROBACULUM AEROPHILUM===




==Overview==
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BACKGROUND: Translation initiation factor 5A (IF-5A) is reported to be involved in the first step of peptide bond formation in translation, to be involved in cell-cycle regulation and to be a cofactor for the Rev and Rex transactivator proteins of human immunodeficiency virus-1 and T-cell leukemia virus I, respectively. IF-5A contains an unusual amino acid, hypusine (N-epsilon-(4-aminobutyl-2-hydroxy)lysine), that is required for its function. The first step in the post-translational modification of lysine to hypusine is catalyzed by the enzyme deoxyhypusine synthase, the structure of which has been published recently. RESULTS: IF-5A from the archebacterium Pyrobaculum aerophilum has been heterologously expressed in Escherichia coli with selenomethionine substitution. The crystal structure of IF-5A has been determined by multiwavelength anomalous diffraction and refined to 1.75 A. Unmodified P. aerophilum IF-5A is found to be a beta structure with two domains and three separate hydrophobic cores. CONCLUSIONS: The lysine (Lys42) that is post-translationally modified by deoxyhypusine synthase is found at one end of the IF-5A molecule in an turn between beta strands beta4 and beta5; this lysine residue is freely solvent accessible. The C-terminal domain is found to be homologous to the cold-shock protein CspA of E. coli, which has a well characterized RNA-binding fold, suggesting that IF-5A is involved in RNA binding.
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{{ABSTRACT_PUBMED_9753699}}


==About this Structure==
==About this Structure==
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[[Category: Waldo, G S.]]
[[Category: Waldo, G S.]]
[[Category: Translation initiation factor]]
[[Category: Translation initiation factor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:37:38 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:18:05 2008''

Revision as of 16:18, 30 June 2008

File:1bkb.png

Template:STRUCTURE 1bkb

INITIATION FACTOR 5A FROM ARCHEBACTERIUM PYROBACULUM AEROPHILUM

Template:ABSTRACT PUBMED 9753699

About this Structure

1BKB is a Single protein structure of sequence from Pyrobaculum aerophilum. Full crystallographic information is available from OCA.

Reference

Structure of translation initiation factor 5A from Pyrobaculum aerophilum at 1.75 A resolution., Peat TS, Newman J, Waldo GS, Berendzen J, Terwilliger TC, Structure. 1998 Sep 15;6(9):1207-14. PMID:9753699

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