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| {{STRUCTURE_1bm0| PDB=1bm0 | SCENE= }} | | {{STRUCTURE_1bm0| PDB=1bm0 | SCENE= }} |
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| '''CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN'''
| | ===CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN=== |
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| ==Overview==
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| A new triclinic crystal form of human serum albumin (HSA), derived either from pool plasma (pHSA) or from a Pichia pastoris expression system (rHSA), was obtained from polyethylene glycol 4000 solution. Three-dimensional structures of pHSA and rHSA were determined at 2.5 A resolution from the new triclinic crystal form by molecular replacement, using atomic coordinates derived from a multiple isomorphous replacement work with a known tetragonal crystal form. The structures of pHSA and rHSA are virtually identical, with an r.m. s. deviation of 0.24 A for all Calpha atoms. The two HSA molecules involved in the asymmetric unit are related by a strict local twofold symmetry such that the Calpha atoms of the two molecules can be superimposed with an r.m.s. deviation of 0.28 A in pHSA. Cys34 is the only cysteine with a free sulfhydryl group which does not participate in a disulfide linkage with any external ligand. Domains II and III both have a pocket formed mostly of hydrophobic and positively charged residues and in which a very wide range of compounds may be accommodated. Three tentative binding sites for long-chain fatty acids, each with different surroundings, are located at the surface of each domain.
| | The line below this paragraph, {{ABSTRACT_PUBMED_10388840}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 10388840 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_10388840}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Albumin]] | | [[Category: Albumin]] |
| [[Category: Carrier protein]] | | [[Category: Carrier protein]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:41:00 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:21:57 2008'' |
