1bmp: Difference between revisions

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[[Image:1bmp.~~gif~~|left|200px]]

[[Image:1bmp.png|left|200px]]

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~~'''~~BONE MORPHOGENETIC PROTEIN-7~~'''~~

===BONE MORPHOGENETIC PROTEIN-7===

~~==Overview==~~

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~~We report the three~~-~~dimensional structure of osteogenic protein 1 (OP~~-1, ~~also known as bone morphogenetic protein 7)~~ to ~~2.8-A resolution. OP-1 is a member of~~ the ~~transforming growth factor beta~~ (TGF-beta) superfamily of proteins and is able to induce new bone formation in vivo. Members of this superfamily share sequence similarity in their C-terminal regions and are implicated in embryonic development and adult tissue repair. ~~Our crystal structure makes possible the structural comparison between two members of the TGF-beta superfamily~~. ~~We find that although there~~ is ~~limited sequence identity between OP-1 and TGF-beta 2, they share a common polypeptide fold. These results establish a basis for proposing~~ the ~~OP-1/TGF-beta 2 fold as the primary structural motif for the TGF-beta superfamily as a whole~~. ~~Detailed comparison of the OP~~-~~1 and TGF~~-~~beta 2 structures has revealed striking differences that provide insights into how these growth factors interact with their receptors.~~

The line below this paragraph, {{ABSTRACT_PUBMED_8570652}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 8570652 is the PubMed ID number.

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==About this Structure==

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[[Category: Morphogen]]

[[Category: Transforming growth factor]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 11~~:42:24 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:23:35 2008''

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-[[Image:1bmp.gif|left|200px]]
+{{Seed}}
+[[Image:1bmp.png|left|200px]]
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 {{STRUCTURE_1bmp|  PDB=1bmp  |  SCENE=  }}
-'''BONE MORPHOGENETIC PROTEIN-7'''
+===BONE MORPHOGENETIC PROTEIN-7===
-==Overview==
+<!--
-We report the three-dimensional structure of osteogenic protein 1 (OP-1, also known as bone morphogenetic protein 7) to 2.8-A resolution. OP-1 is a member of the transforming growth factor beta (TGF-beta) superfamily of proteins and is able to induce new bone formation in vivo. Members of this superfamily share sequence similarity in their C-terminal regions and are implicated in embryonic development and adult tissue repair. Our crystal structure makes possible the structural comparison between two members of the TGF-beta superfamily. We find that although there is limited sequence identity between OP-1 and TGF-beta 2, they share a common polypeptide fold. These results establish a basis for proposing the OP-1/TGF-beta 2 fold as the primary structural motif for the TGF-beta superfamily as a whole. Detailed comparison of the OP-1 and TGF-beta 2 structures has revealed striking differences that provide insights into how these growth factors interact with their receptors.
+The line below this paragraph, {{ABSTRACT_PUBMED_8570652}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8570652 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8570652}}
 ==About this Structure==
@@ Line 30: / Line 34: @@
 [[Category: Morphogen]]
 [[Category: Transforming growth factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:42:24 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:23:35 2008''