1bn0: Difference between revisions

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[[Image:1bn0.gif|left|200px]]
{{Seed}}
[[Image:1bn0.png|left|200px]]


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{{STRUCTURE_1bn0|  PDB=1bn0  |  SCENE=  }}  
{{STRUCTURE_1bn0|  PDB=1bn0  |  SCENE=  }}  


'''SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES'''
===SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES===




==Overview==
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An NMR-based structure is presented for a 20 mer hairpin model of the SL3 stem-loop from the HIV-1 packaging signal. The stem has an A-family structure. However, the GGAG tetraloop appears to be flexible with the second (G10) and fourth (G12) bases extruded from the normal stacking arrangement. The A-base (A11) occupies a cavity large enough for it to jump rapidly between stacking upon G9 (in the loop) and G13 (from the base-pair adjacent to the loop). The H-bonding loci of G10, A11, and G12 are unoccupied in the free RNA structure. The loop should be easily adaptable to binding by the HIV-1 nucleocapsid protein or loop receptors.
The line below this paragraph, {{ABSTRACT_PUBMED_9743628}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9743628 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9743628}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BN0 OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BN0 OCA].  


==Reference==
==Reference==
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[[Category: Rna]]
[[Category: Rna]]
[[Category: Tetraloop]]
[[Category: Tetraloop]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:43:04 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:24:10 2008''

Revision as of 16:24, 30 June 2008

File:1bn0.png

Template:STRUCTURE 1bn0

SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES

Template:ABSTRACT PUBMED 9743628

About this Structure

Full experimental information is available from OCA.

Reference

Three-dimensional folding of an RNA hairpin required for packaging HIV-1., Pappalardo L, Kerwood DJ, Pelczer I, Borer PN, J Mol Biol. 1998 Oct 2;282(4):801-18. PMID:9743628

Page seeded by OCA on Mon Jun 30 19:24:10 2008

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