1bpv: Difference between revisions

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[[Image:1bpv.gif|left|200px]]
{{Seed}}
[[Image:1bpv.png|left|200px]]


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{{STRUCTURE_1bpv|  PDB=1bpv  |  SCENE=  }}  
{{STRUCTURE_1bpv|  PDB=1bpv  |  SCENE=  }}  


'''TITIN MODULE A71 FROM HUMAN CARDIAC MUSCLE, NMR, 50 STRUCTURES'''
===TITIN MODULE A71 FROM HUMAN CARDIAC MUSCLE, NMR, 50 STRUCTURES===




==Overview==
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BACKGROUND: Titin is a huge protein ( approximately 3 MDa) that is present in the contractile unit (sarcomere) of striated muscle and has a key role in muscle assembly and elasticity. Titin is mainly composed of two types of module (type I and II). Type I modules are found exclusively in the region of titin localised in the A band, where they are arranged in a super-repeat pattern that correlates with the ultrastructure of the thick filament. No structure of a titin type I module has been reported so far. RESULTS: We have determined the structure of a representative type I module, A71, using nuclear magnetic resonance (NMR) spectroscopy. The structure has the predicted fibronectin type III fold. Titin-specific conserved residues are either located at the putative module-module interfaces or along one side of the protein surface. Several proline residues that contribute to two stretches in a polyproline II helix conformation are solvent-exposed and line up as a continuous ribbon extending over more than two-thirds of the module surface. Homology models of the type I module N-terminal to A71 (A70) and the double module A70-A71 were used to discuss possible intermodule interactions and their role in module-module orientation. CONCLUSIONS: As residues at the module-module interfaces are highly conserved, we speculate that similar interactions govern all of the interfaces between type I modules in titin. This conservation would lead to a regular multiple array of similar surface structures. Such an arrangement would allow arrays of contiguous type I modules to expose multiple proline stretches in a highly regular way and these may act as binding sites for other thick filament proteins.
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{{ABSTRACT_PUBMED_9782056}}


==About this Structure==
==About this Structure==
1BPV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPV OCA].  
1BPV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BPV OCA].  


==Reference==
==Reference==
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[[Category: Fibronectin type iii]]
[[Category: Fibronectin type iii]]
[[Category: Titin]]
[[Category: Titin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:48:31 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:30:34 2008''

Revision as of 16:30, 30 June 2008

File:1bpv.png

Template:STRUCTURE 1bpv

TITIN MODULE A71 FROM HUMAN CARDIAC MUSCLE, NMR, 50 STRUCTURES

Template:ABSTRACT PUBMED 9782056

About this Structure

1BPV is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The three-dimensional structure of a type I module from titin: a prototype of intracellular fibronectin type III domains., Goll CM, Pastore A, Nilges M, Structure. 1998 Oct 15;6(10):1291-302. PMID:9782056

Page seeded by OCA on Mon Jun 30 19:30:34 2008

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