1bti: Difference between revisions

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[[Image:1bti.~~jpg~~|left|200px]]

[[Image:1bti.png|left|200px]]

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~~'''~~CREVICE-FORMING MUTANTS IN THE RIGID CORE OF BOVINE PANCREATIC TRYPSIN INHIBITOR: CRYSTAL STRUCTURES OF F22A, Y23A, N43G, AND F45A~~'''~~

===CREVICE-FORMING MUTANTS IN THE RIGID CORE OF BOVINE PANCREATIC TRYPSIN INHIBITOR: CRYSTAL STRUCTURES OF F22A, Y23A, N43G, AND F45A===

~~==Overview==~~

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~~Crystal structures of four mutants of bovine pancreatic trypsin inhibitor (F22A, Y23A, N43G, and F45A), engineered to alter their stability properties, have been determined.~~ The ~~mutated residues~~, ~~which are highly conserved among Kunitz-type inhibitors~~, ~~are located in~~ the ~~rigid core of~~ the ~~molecule~~. ~~Replacement of the partially buried bulky residues of the wild-type protein with smaller residues resulted in crevices open to the exterior of~~ the ~~molecule~~. ~~The overall three~~-~~dimensional structure of these mutants is very similar to that of the wild~~-~~type protein and only small rearrangements are observed among the atoms lining the crevices.~~

The line below this paragraph, {{ABSTRACT_PUBMED_8518731}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 8518731 is the PubMed ID number.

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==About this Structure==

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[[Category: Woodward, C.]]

[[Category: Serine protease inhibitor]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 11~~:56:19 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:41:49 2008''

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-[[Image:1bti.jpg|left|200px]]
+{{Seed}}
+[[Image:1bti.png|left|200px]]
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 {{STRUCTURE_1bti|  PDB=1bti  |  SCENE=  }}
-'''CREVICE-FORMING MUTANTS IN THE RIGID CORE OF BOVINE PANCREATIC TRYPSIN INHIBITOR: CRYSTAL STRUCTURES OF F22A, Y23A, N43G, AND F45A'''
+===CREVICE-FORMING MUTANTS IN THE RIGID CORE OF BOVINE PANCREATIC TRYPSIN INHIBITOR: CRYSTAL STRUCTURES OF F22A, Y23A, N43G, AND F45A===
-==Overview==
+<!--
-Crystal structures of four mutants of bovine pancreatic trypsin inhibitor (F22A, Y23A, N43G, and F45A), engineered to alter their stability properties, have been determined. The mutated residues, which are highly conserved among Kunitz-type inhibitors, are located in the rigid core of the molecule. Replacement of the partially buried bulky residues of the wild-type protein with smaller residues resulted in crevices open to the exterior of the molecule. The overall three-dimensional structure of these mutants is very similar to that of the wild-type protein and only small rearrangements are observed among the atoms lining the crevices.
+The line below this paragraph, {{ABSTRACT_PUBMED_8518731}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8518731 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8518731}}
 ==About this Structure==
@@ Line 29: / Line 33: @@
 [[Category: Woodward, C.]]
 [[Category: Serine protease inhibitor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:56:19 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:41:49 2008''