1btr: Difference between revisions

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[[Image:1btr.gif|left|200px]]
{{Seed}}
[[Image:1btr.png|left|200px]]


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{{STRUCTURE_1btr|  PDB=1btr  |  SCENE=  }}  
{{STRUCTURE_1btr|  PDB=1btr  |  SCENE=  }}  


'''THE SOLUTION STRUCTURES OF THE FIRST AND SECOND TRANSMEMBRANE-SPANNING SEGMENTS OF BAND 3'''
===THE SOLUTION STRUCTURES OF THE FIRST AND SECOND TRANSMEMBRANE-SPANNING SEGMENTS OF BAND 3===




==Overview==
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We have studied the structures of synthetic peptides which correspond to the proposed first and second membrane-spanning segments of the human red cell anion transporter (band 3). The peptides, which were acetylated at their N-termini and amidated at the C-termini, comprise the 20 amino acids of residues 405-424 and 21 amino acids of residues 436-456 of the human band 3 sequence. The solution structures of the peptides in trifluoroethanol were studied by two-dimensional NMR spectroscopy. Characteristic NOEs were observed indicating that the peptides adopted a predominantly alpha-helical structure in trifluoroethanol solution. Dynamical simulated annealing using the program XPLOR was employed for the structure calculations. The amide exchange rates in trifluoroethanol have also been measured and are consistent with an alpha-helical structure for the peptides.
The line below this paragraph, {{ABSTRACT_PUBMED_8168533}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_8168533}}


==About this Structure==
==About this Structure==
1BTR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BTR OCA].  
1BTR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BTR OCA].  


==Reference==
==Reference==
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[[Category: Tanner, M J.A.]]
[[Category: Tanner, M J.A.]]
[[Category: Anion transport]]
[[Category: Anion transport]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:56:46 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:42:35 2008''

Revision as of 16:42, 30 June 2008

File:1btr.png

Template:STRUCTURE 1btr

THE SOLUTION STRUCTURES OF THE FIRST AND SECOND TRANSMEMBRANE-SPANNING SEGMENTS OF BAND 3

Template:ABSTRACT PUBMED 8168533

About this Structure

1BTR is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The solution structures of the first and second transmembrane-spanning segments of band 3., Gargaro AR, Bloomberg GB, Dempsey CE, Murray M, Tanner MJ, Eur J Biochem. 1994 Apr 1;221(1):445-54. PMID:8168533

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