1bui: Difference between revisions

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[[Image:1bui.jpg|left|200px]]
{{Seed}}
[[Image:1bui.png|left|200px]]


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{{STRUCTURE_1bui|  PDB=1bui  |  SCENE=  }}  
{{STRUCTURE_1bui|  PDB=1bui  |  SCENE=  }}  


'''STRUCTURE OF THE TERNARY MICROPLASMIN-STAPHYLOKINASE-MICROPLASMIN COMPLEX: A PROTEINASE-COFACTOR-SUBSTRATE COMPLEX IN ACTION.'''
===STRUCTURE OF THE TERNARY MICROPLASMIN-STAPHYLOKINASE-MICROPLASMIN COMPLEX: A PROTEINASE-COFACTOR-SUBSTRATE COMPLEX IN ACTION.===




==Overview==
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The serine proteinase plasmin is the key fibrinolytic enzyme that dissolves blood clots and also promotes cell migration and tissue remodeling. Here, we report the 2.65 A crystal structure of a ternary complex of microplasmin-staphylokinase bound to a second microplasmin. The staphylokinase 'cofactor' does not affect the active-site geometry of the plasmin 'enzyme', but instead modifies its subsite specificity by providing additional docking sites for enhanced presentation of the plasminogen 'substrate' to the 'enzymes's' active site. The activation loop of the plasmin 'substrate', cleaved in these crystals, can be reconstructed to show how it runs across the active site of the plasmin 'enzyme' prior to activation cleavage. This is the first experimental structure of a productive proteinase-cofactor-macromolecular substrate complex. Furthermore, it provides a template for the design of improved plasminogen activators and plasmin inhibitors with considerable therapeutical potential.
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==About this Structure==
==About this Structure==
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[[Category: Serine proteinase]]
[[Category: Serine proteinase]]
[[Category: Staphylokinase]]
[[Category: Staphylokinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:58:21 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:44:31 2008''

Revision as of 16:44, 30 June 2008

File:1bui.png

Template:STRUCTURE 1bui

STRUCTURE OF THE TERNARY MICROPLASMIN-STAPHYLOKINASE-MICROPLASMIN COMPLEX: A PROTEINASE-COFACTOR-SUBSTRATE COMPLEX IN ACTION.

Template:ABSTRACT PUBMED 9783753

About this Structure

1BUI is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The ternary microplasmin-staphylokinase-microplasmin complex is a proteinase-cofactor-substrate complex in action., Parry MA, Fernandez-Catalan C, Bergner A, Huber R, Hopfner KP, Schlott B, Guhrs KH, Bode W, Nat Struct Biol. 1998 Oct;5(10):917-23. PMID:9783753

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