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| [[Image:1bv4.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1bv4| PDB=1bv4 | SCENE= }} | | {{STRUCTURE_1bv4| PDB=1bv4 | SCENE= }} |
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| '''APO-MANNOSE-BINDING PROTEIN-C'''
| | ===APO-MANNOSE-BINDING PROTEIN-C=== |
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| ==Overview==
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| C-type animal lectins are a diverse family of proteins which mediate cell-surface carbohydrate-recognition events through a conserved carbohydrate-recognition domain (CRD). Most members of this family possess a carbohydrate-binding activity that depends strictly on the binding of Ca2+ at two sites, designated 1 and 2, in the CRD. The structural transitions associated with Ca2+ binding in C-type lectins have been investigated by determining high-resolution crystal structures of rat serum mannose-binding protein (MBP) bound to one Ho3+ in place of Ca2+, and the apo form of rat liver MBP. The removal of Ca2+ does not affect the core structure of the CRD, but dramatic conformational changes occur in the loops. The most significant structural change in the absence of Ca2+ is the isomerization of a cis-peptide bond preceding a conserved proline residue in Ca2+ site 2. This bond adopts the cis conformation in all Ca2+-bound structures, whereas both cis and trans conformations are observed in the absence of Ca2+. The pattern of structural changes in the three loops that interact with Ca2+ is dictated in large part by the conformation of the prolyl peptide bond. The highly conserved nature of Ca2+ site 2 suggests that the transitions observed in MBPs are general features of Ca2+ binding in C-type lectins.
| | The line below this paragraph, {{ABSTRACT_PUBMED_9922165}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 9922165 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_9922165}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Calcium-binding protein]] | | [[Category: Calcium-binding protein]] |
| [[Category: Collectin]] | | [[Category: Collectin]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:59:28 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:46:02 2008'' |
