1bvk: Difference between revisions

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[[Image:1bvk.gif|left|200px]]
{{Seed}}
[[Image:1bvk.png|left|200px]]


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{{STRUCTURE_1bvk|  PDB=1bvk  |  SCENE=  }}  
{{STRUCTURE_1bvk|  PDB=1bvk  |  SCENE=  }}  


'''HUMANIZED ANTI-LYSOZYME FV COMPLEXED WITH LYSOZYME'''
===HUMANIZED ANTI-LYSOZYME FV COMPLEXED WITH LYSOZYME===




==Overview==
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The crystal structure of the complex between hen egg lysozyme and the Fv fragment of a humanized antilysozyme antibody was determined to 2.7-A resolution. The structure of the antigen combining site in the complex is nearly identical to that of the complexed form of the parent mouse antibody, D1.3. In contrast, the combining sites of the unliganded mouse and humanized antilysozymes show moderate conformational differences. This disparity suggests that a conformational readjustment process linked to antigen binding reverses adverse conformations in the complementarity determining regions that had been introduced by engineering these segments next to human framework regions in the humanized antibody.
The line below this paragraph, {{ABSTRACT_PUBMED_9463398}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9463398 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9463398}}


==About this Structure==
==About this Structure==
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[[Category: Fv]]
[[Category: Fv]]
[[Category: Humanized antibody]]
[[Category: Humanized antibody]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:00:24 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:47:12 2008''

Revision as of 16:47, 30 June 2008

File:1bvk.png

Template:STRUCTURE 1bvk

HUMANIZED ANTI-LYSOZYME FV COMPLEXED WITH LYSOZYME

Template:ABSTRACT PUBMED 9463398

About this Structure

1BVK is a Protein complex structure of sequences from Gallus gallus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Conformational correction mechanisms aiding antigen recognition by a humanized antibody., Holmes MA, Buss TN, Foote J, J Exp Med. 1998 Feb 16;187(4):479-85. PMID:9463398

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