1bw7: Difference between revisions

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[[Image:1bw7.jpg|left|200px]]
{{Seed}}
[[Image:1bw7.png|left|200px]]


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{{STRUCTURE_1bw7|  PDB=1bw7  |  SCENE=  }}  
{{STRUCTURE_1bw7|  PDB=1bw7  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF A DNA DUPLEX CONTAINING A REPLICABLE DIFLUOROTOLUENE-ADENINE PAIR'''
===SOLUTION STRUCTURE OF A DNA DUPLEX CONTAINING A REPLICABLE DIFLUOROTOLUENE-ADENINE PAIR===




==Overview==
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A nonpolar aromatic nucleoside derivative based on 2,4-difluorotoluene (F), a non-hydrogen bonding shape analog of thymidine, was recently shown to be replicated against adenine with high efficiency and fidelity. This led to the suggestion that geometric matching, potentially even in the absence of hydrogen bonding between bases in a pair, may be sufficient to direct nucleotide selection during replication. We have examined the solution structure of the F-A pair in the context of a 12 base pair DNA duplex. We find that, despite the destabilization caused by this analog, the F-A pair very closely resembles that of a T x A pair in the same context. This lends support to the importance of shape matching in replication.
The line below this paragraph, {{ABSTRACT_PUBMED_9808039}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9808039 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9808039}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BW7 OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BW7 OCA].  


==Reference==
==Reference==
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[[Category: Difluorotoluene]]
[[Category: Difluorotoluene]]
[[Category: Dna]]
[[Category: Dna]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:01:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:48:49 2008''

Revision as of 16:48, 30 June 2008

File:1bw7.png

Template:STRUCTURE 1bw7

SOLUTION STRUCTURE OF A DNA DUPLEX CONTAINING A REPLICABLE DIFLUOROTOLUENE-ADENINE PAIR

Template:ABSTRACT PUBMED 9808039

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of a DNA duplex containing a replicable difluorotoluene-adenine pair., Guckian KM, Krugh TR, Kool ET, Nat Struct Biol. 1998 Nov;5(11):954-9. PMID:9808039

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