1bxt: Difference between revisions

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[[Image:1bxt.gif|left|200px]]
{{Seed}}
[[Image:1bxt.png|left|200px]]


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{{STRUCTURE_1bxt|  PDB=1bxt  |  SCENE=  }}  
{{STRUCTURE_1bxt|  PDB=1bxt  |  SCENE=  }}  


'''STREPTOCOCCAL SUPERANTIGEN (SSA) FROM STREPTOCOCCUS PYOGENES'''
===STREPTOCOCCAL SUPERANTIGEN (SSA) FROM STREPTOCOCCUS PYOGENES===




==Overview==
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Streptococcal superantigen (SSA) is a 28,000 Mr toxin originally isolated from a pathogenic strain of Streptococcus pyogenes that has 60% sequence identity with staphylococcal enterotoxin B (SEB). SSA and SEB, however, do not compete for binding on the surfaces of cells expressing MHC class II molecules. This behavior had been ascribed to SSA and SEB binding to distinct sites on, or different subsets of, HLA-DR molecules. Here we demonstrate that SSA binds predominantly to HLA-DQ, rather than to HLA-DR molecules, and present the crystal structure of SSA at 1.85 A resolution. These data provide a structural basis for interpreting the interaction of SSA with HLA-DQ molecules as well as a foundation for understanding bacterial superantigen affinities for distinct MHC isotypes.
The line below this paragraph, {{ABSTRACT_PUBMED_10048922}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10048922 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10048922}}


==About this Structure==
==About this Structure==
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[[Category: T cell activation]]
[[Category: T cell activation]]
[[Category: Toxic shock-like syndrome]]
[[Category: Toxic shock-like syndrome]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:05:30 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 19:53:17 2008''

Revision as of 16:53, 30 June 2008

File:1bxt.png

Template:STRUCTURE 1bxt

STREPTOCOCCAL SUPERANTIGEN (SSA) FROM STREPTOCOCCUS PYOGENES

Template:ABSTRACT PUBMED 10048922

About this Structure

1BXT is a Single protein structure of sequence from Streptococcus pyogenes. Full crystallographic information is available from OCA.

Reference

Structural basis for HLA-DQ binding by the streptococcal superantigen SSA., Sundberg E, Jardetzky TS, Nat Struct Biol. 1999 Feb;6(2):123-9. PMID:10048922

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