6rb3: Difference between revisions

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<StructureSection load='6rb3' size='340' side='right'caption='[[6rb3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='6rb3' size='340' side='right'caption='[[6rb3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6rb3]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"mycobacterium_abcessus"_moore_and_frerichs_1953 "mycobacterium abcessus" moore and frerichs 1953]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RB3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RB3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6rb3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacteroides_abscessus Mycobacteroides abscessus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RB3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RB3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JWW:2-heptylquinoline-3,4-diol'>JWW</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAB_0303 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36809 "Mycobacterium abcessus" Moore and Frerichs 1953])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JWW:2-heptylquinoline-3,4-diol'>JWW</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rb3 OCA], [http://pdbe.org/6rb3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rb3 RCSB], [http://www.ebi.ac.uk/pdbsum/6rb3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rb3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rb3 OCA], [https://pdbe.org/6rb3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rb3 RCSB], [https://www.ebi.ac.uk/pdbsum/6rb3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rb3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AQDC_MYCA9 AQDC_MYCA9] Ring-cleaving dioxygenase involved in the degradation pathway of the Pseudomonas aeruginosa quorum sensing signal molecules HHQ (2-heptyl-4-quinolone) and PQS (2-heptyl-3-hydroxy-4(1H)-quinolone) to anthranilate. Catalyzes the cleavage of PQS to form N-octanoylanthranilate and carbon monoxide. Thus, leads to the inactivation of PQS that plays a central role in the regulation of virulence factor production by P.aeruginosa, thereby quenching the production of antimicrobials, which may contribute to the competitiveness of M.abscessus in presence of P.aeruginosa (PubMed:31228546, PubMed:28303132). In vitro, can also use other 2-alkyl-3-hydroxy-4(1H)-quinolone (AHQ) substrates with shorter alkyl substituents at C2, but with lower efficiency (PubMed:31228546).<ref>PMID:28303132</ref> <ref>PMID:31228546</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Mycobacterium abcessus moore and frerichs 1953]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Fetzner, S]]
[[Category: Mycobacteroides abscessus]]
[[Category: Kobus, S]]
[[Category: Fetzner S]]
[[Category: Smits, S H]]
[[Category: Kobus S]]
[[Category: Wullich, S]]
[[Category: Smits SH]]
[[Category: Alpha/beta hydrolase fold]]
[[Category: Wullich S]]
[[Category: Catalytic triad]]
[[Category: Dioxygenase]]
[[Category: Hydrolase]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas quinolone signal]]
[[Category: Quorum sensing]]
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