2vlw: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[2vlw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VLW OCA]. For a guided tour on the structure components use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VLW FirstGlance].

<table><tr><td colspan='2'>[[2vlw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VLW OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=2VLW FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=TYI:3,5-DIIODOTYROSINE'>TYI</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vlw OCA], [~~http~~://pdbe.org/2vlw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vlw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vlw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vlw ProSAT]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=2vlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vlw OCA], [https://pdbe.org/2vlw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vlw RCSB], [https://www.ebi.ac.uk/pdbsum/2vlw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vlw ProSAT]</td></tr>

</table>

== Function ==

[[~~http~~://www.uniprot.org/uniprot/NXM11_DENAN NXM11_DENAN]] Binds irreversibly and specifically to M1 (CHRM1) muscarinic acetylcholine receptors, blocking further binding of antagonists and preventing the action of agonists.<ref>PMID:11562434</ref> <ref>PMID:10799315</ref>

[[https://www.uniprot.org/uniprot/NXM11_DENAN NXM11_DENAN]] Binds irreversibly and specifically to M1 (CHRM1) muscarinic acetylcholine receptors, blocking further binding of antagonists and preventing the action of agonists.<ref>PMID:11562434</ref> <ref>PMID:10799315</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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@@ Line 3: / Line 3: @@
 <StructureSection load='2vlw' size='340' side='right'caption='[[2vlw]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2vlw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VLW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VLW FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2vlw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VLW FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYI:3,5-DIIODOTYROSINE'>TYI</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vlw OCA], [http://pdbe.org/2vlw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vlw RCSB], [http://www.ebi.ac.uk/pdbsum/2vlw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vlw ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vlw OCA], [https://pdbe.org/2vlw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vlw RCSB], [https://www.ebi.ac.uk/pdbsum/2vlw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vlw ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/NXM11_DENAN NXM11_DENAN]] Binds irreversibly and specifically to M1 (CHRM1) muscarinic acetylcholine receptors, blocking further binding of antagonists and preventing the action of agonists.<ref>PMID:11562434</ref> <ref>PMID:10799315</ref>
+[[https://www.uniprot.org/uniprot/NXM11_DENAN NXM11_DENAN]] Binds irreversibly and specifically to M1 (CHRM1) muscarinic acetylcholine receptors, blocking further binding of antagonists and preventing the action of agonists.<ref>PMID:11562434</ref> <ref>PMID:10799315</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]