2w2j: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[2w2j]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2J OCA]. For a guided tour on the structure components use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2W2J FirstGlance].

<table><tr><td colspan='2'>[[2w2j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2J OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=2W2J FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[~~http~~://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[https://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[~~http~~://proteopedia.org/fgij/fg.htm?mol=2w2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w2j OCA], [~~http~~://pdbe.org/2w2j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2w2j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2w2j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2w2j ProSAT]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=2w2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w2j OCA], [https://pdbe.org/2w2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w2j RCSB], [https://www.ebi.ac.uk/pdbsum/2w2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w2j ProSAT]</td></tr>

</table>

== Disease ==

[[~~http~~://www.uniprot.org/uniprot/CAH8_HUMAN CAH8_HUMAN]] Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3) [MIM:[~~http~~://omim.org/entry/613227 613227]]. CMARQ3 is a congenital cerebellar ataxia associated with dysarthia, quadrupedal gait and mild mental retardation.

[[https://www.uniprot.org/uniprot/CAH8_HUMAN CAH8_HUMAN]] Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3) [MIM:[https://omim.org/entry/613227 613227]]. CMARQ3 is a congenital cerebellar ataxia associated with dysarthia, quadrupedal gait and mild mental retardation.

== Function ==

[[~~http~~://www.uniprot.org/uniprot/CAH8_HUMAN CAH8_HUMAN]] Does not have a carbonic anhydrase catalytic activity.

[[https://www.uniprot.org/uniprot/CAH8_HUMAN CAH8_HUMAN]] Does not have a carbonic anhydrase catalytic activity.

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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 <StructureSection load='2w2j' size='340' side='right'caption='[[2w2j]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2w2j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2J OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2W2J FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2w2j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W2J FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2w2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w2j OCA], [http://pdbe.org/2w2j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w2j RCSB], [http://www.ebi.ac.uk/pdbsum/2w2j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w2j ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w2j OCA], [https://pdbe.org/2w2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w2j RCSB], [https://www.ebi.ac.uk/pdbsum/2w2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w2j ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[http://www.uniprot.org/uniprot/CAH8_HUMAN CAH8_HUMAN]] Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3) [MIM:[http://omim.org/entry/613227 613227]]. CMARQ3 is a congenital cerebellar ataxia associated with dysarthia, quadrupedal gait and mild mental retardation.
+[[https://www.uniprot.org/uniprot/CAH8_HUMAN CAH8_HUMAN]] Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3) [MIM:[https://omim.org/entry/613227 613227]]. CMARQ3 is a congenital cerebellar ataxia associated with dysarthia, quadrupedal gait and mild mental retardation.
 == Function ==
-[[http://www.uniprot.org/uniprot/CAH8_HUMAN CAH8_HUMAN]] Does not have a carbonic anhydrase catalytic activity.
+[[https://www.uniprot.org/uniprot/CAH8_HUMAN CAH8_HUMAN]] Does not have a carbonic anhydrase catalytic activity.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]