NudT16: Difference between revisions
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== Relevance == | == Relevance == | ||
Nudix enzymes are found in every organism in the three domains of life, signifying the importance of phosphodiester bond hydrolysis. <ref>PMID: 16378245</ref> | Nudix enzymes are found in every organism in the three domains of life, signifying the importance of phosphodiester bond hydrolysis. <ref>PMID: 16378245</ref> | ||
One of the most biologically important processes NudT16 plays a role in is ADP ribosylation, a post-translational modification that can change various amino acids by conjugating the ADP ribose with the protein. HsNudT16 can reverse ADP ribosylation through hydrolysis of inosine triphosphate or diphosphate. | One of the most biologically important processes NudT16 plays a role in is ADP ribosylation, a post-translational modification that can change various amino acids by conjugating the ADP ribose with the protein. HsNudT16 can reverse ADP ribosylation through hydrolysis of inosine triphosphate or diphosphate. NudT16 plays a crucial role in the cell cycle as its absence in HeLa MR cells caused cell arrest during the S phase. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
