1c14: Difference between revisions

Line 1:

[[Image:1c14.~~gif~~|left|200px]]

[[Image:1c14.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~CRYSTAL STRUCTURE OF E COLI ENOYL REDUCTASE-NAD+-TRICLOSAN COMPLEX~~'''~~

===CRYSTAL STRUCTURE OF E COLI ENOYL REDUCTASE-NAD+-TRICLOSAN COMPLEX===

~~==Overview==~~

<!--

The ~~crystal structure of~~ the ~~Escherichia coli enoyl reductase-NAD+-triclosan complex has been determined~~ at 2.~~5 A resolution~~. ~~The Ile192-Ser198 loop~~ is ~~either disordered or in an open conformation in the previously reported structures of~~ the ~~enzyme~~. This loop adopts a closed conformation in our structure, forming van der Waals interactions with the inhibitor and hydrogen bonds with the bound NAD+ cofactor. The opening and closing of this flipping loop is likely an important factor in substrate or ligand recognition. The closed conformation of the loop appears to be a critical feature for the enhanced binding potency of triclosan, and a key component in future structure-~~based inhibitor design.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10595560}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10595560 is the PubMed ID number.

-->

==About this Structure==

Line 32:

Line 36:

[[Category: Oxidoreductase]]

[[Category: Triclosan]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 12~~:12:17 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:03:48 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1c14.gif|left|200px]]
+{{Seed}}
+[[Image:1c14.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1c14|  PDB=1c14  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF E COLI ENOYL REDUCTASE-NAD+-TRICLOSAN COMPLEX'''
+===CRYSTAL STRUCTURE OF E COLI ENOYL REDUCTASE-NAD+-TRICLOSAN COMPLEX===
-==Overview==
+<!--
-The crystal structure of the Escherichia coli enoyl reductase-NAD+-triclosan complex has been determined at 2.5 A resolution. The Ile192-Ser198 loop is either disordered or in an open conformation in the previously reported structures of the enzyme. This loop adopts a closed conformation in our structure, forming van der Waals interactions with the inhibitor and hydrogen bonds with the bound NAD+ cofactor. The opening and closing of this flipping loop is likely an important factor in substrate or ligand recognition. The closed conformation of the loop appears to be a critical feature for the enhanced binding potency of triclosan, and a key component in future structure-based inhibitor design.
+The line below this paragraph, {{ABSTRACT_PUBMED_10595560}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10595560 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10595560}}
 ==About this Structure==
@@ Line 32: / Line 36: @@
 [[Category: Oxidoreductase]]
 [[Category: Triclosan]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:12:17 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:03:48 2008''