1c16: Difference between revisions

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[[Image:1c16.~~gif~~|left|200px]]

[[Image:1c16.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE ANALYSIS OF THE GAMMA/DELTA T CELL LIGAND T22~~'''~~

===CRYSTAL STRUCTURE ANALYSIS OF THE GAMMA/DELTA T CELL LIGAND T22===

~~==Overview==~~

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~~Murine T10 and T22 are highly related nonclassical major histocompatibility complex (MHC) class Ib proteins that bind~~ to ~~certain gammadelta T cell receptors~~ (~~TCRs) in the absence of other components~~. ~~The crystal structure of T22b at 3~~.~~1 angstroms reveals similarities to MHC class I molecules~~, ~~but one side of the normal peptide-binding groove~~ is ~~severely truncated, which allows direct access to~~ the ~~beta-sheet floor~~. ~~Potential gammadelta TCR~~-~~binding sites can be inferred from functional mapping of T10 and T22 point mutants and allelic variants. Thus, T22 represents an unusual variant of the MHC~~-~~like fold and indicates that gammadelta and alphabeta TCRs interact differently with their respective MHC ligands.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10634787}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10634787 is the PubMed ID number.

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==About this Structure==

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[[Category: Major histocompatibility]]

[[Category: Non-classical mhc-like]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 12~~:12:32 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:04:03 2008''

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-[[Image:1c16.gif|left|200px]]
+{{Seed}}
+[[Image:1c16.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1c16|  PDB=1c16  |  SCENE=  }}
-'''CRYSTAL STRUCTURE ANALYSIS OF THE GAMMA/DELTA T CELL LIGAND T22'''
+===CRYSTAL STRUCTURE ANALYSIS OF THE GAMMA/DELTA T CELL LIGAND T22===
-==Overview==
+<!--
-Murine T10 and T22 are highly related nonclassical major histocompatibility complex (MHC) class Ib proteins that bind to certain gammadelta T cell receptors (TCRs) in the absence of other components. The crystal structure of T22b at 3.1 angstroms reveals similarities to MHC class I molecules, but one side of the normal peptide-binding groove is severely truncated, which allows direct access to the beta-sheet floor. Potential gammadelta TCR-binding sites can be inferred from functional mapping of T10 and T22 point mutants and allelic variants. Thus, T22 represents an unusual variant of the MHC-like fold and indicates that gammadelta and alphabeta TCRs interact differently with their respective MHC ligands.
+The line below this paragraph, {{ABSTRACT_PUBMED_10634787}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10634787 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10634787}}
 ==About this Structure==
@@ Line 31: / Line 35: @@
 [[Category: Major histocompatibility]]
 [[Category: Non-classical mhc-like]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:12:32 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:04:03 2008''