1c1e: Difference between revisions

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[[Image:1c1e.jpg|left|200px]]
[[Image:1c1e.png|left|200px]]


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==Overview==
{{ABSTRACT_10600746}}
The crystal structure of an efficient Diels-Alder antibody catalyst at 1.9 angstrom resolution reveals almost perfect shape complementarity with its transition state analog. Comparison with highly related progesterone and Diels-Alderase antibodies that arose from the same primordial germ line template shows the relatively subtle mutational steps that were able to evolve both structural complementarity and catalytic efficiency.


==About this Structure==
==About this Structure==
The following page contains interesting information on the relation of 1C1E with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb21_1.html Antibodies]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1E OCA].  
The following page contains interesting information on the relation of 1C1E with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb21_1.html Antibodies]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1E OCA].  
==Reference==
Evolution of shape complementarity and catalytic efficiency from a primordial antibody template., Xu J, Deng Q, Chen J, Houk KN, Bartek J, Hilvert D, Wilson IA, Science. 1999 Dec 17;286(5448):2345-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10600746 10600746]
[[Category: Antibodies]]
[[Category: Antibodies]]
[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
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[[Category: Diels-alder]]
[[Category: Diels-alder]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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