1c3w: Difference between revisions

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[[Image:1c3w.gif|left|200px]]
[[Image:1c3w.png|left|200px]]


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==Overview==
{{ABSTRACT_10452895}}
Th?e atomic structure of the light-driven ion pump bacteriorhodopsin and the surrounding lipid matrix was determined by X-ray diffraction of crystals grown in cubic lipid phase. In the extracellular region, an extensive three-dimensional hydrogen-bonded network of protein residues and seven water molecules leads from the buried retinal Schiff base and the proton acceptor Asp85 to the membrane surface. Near Lys216 where the retinal binds, transmembrane helix G contains a pi-bulge that causes a non-proline? kink. The bulge is stabilized by hydrogen-bonding of the main-chain carbonyl groups of Ala215 and Lys216 with two buried water molecules located between the Schiff base and the proton donor Asp96 in the cytoplasmic region. The results indicate extensive involvement of bound water molecules in both the structure and the function of this seven-helical membrane protein. A bilayer of 18 tightly bound lipid chains forms an annulus around the protein in the crystal. Contacts between the trimers in the membrane plane are mediated almost exclusively by lipids.


==About this Structure==
==About this Structure==
1C3W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Halobacterium_salinarum Halobacterium salinarum]. The following page contains interesting information on the relation of 1C3W with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb27_1.html Bacteriorhodopsin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C3W OCA].  
1C3W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Halobacterium_salinarum Halobacterium salinarum]. The following page contains interesting information on the relation of 1C3W with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb27_1.html Bacteriorhodopsin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C3W OCA].  
==Reference==
Structure of bacteriorhodopsin at 1.55 A resolution., Luecke H, Schobert B, Richter HT, Cartailler JP, Lanyi JK, J Mol Biol. 1999 Aug 27;291(4):899-911. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10452895 10452895]
[[Category: Bacteriorhodopsin]]
[[Category: Bacteriorhodopsin]]
[[Category: Halobacterium salinarum]]
[[Category: Halobacterium salinarum]]
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[[Category: Retinal protein]]
[[Category: Retinal protein]]
[[Category: Serpentine]]
[[Category: Serpentine]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:17:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:06:30 2008''

Revision as of 14:06, 26 June 2008

File:1c3w.png

Template:STRUCTURE 1c3w

BACTERIORHODOPSIN/LIPID COMPLEX AT 1.55 A RESOLUTION


Template:ABSTRACT 10452895

About this Structure

1C3W is a Single protein structure of sequence from Halobacterium salinarum. The following page contains interesting information on the relation of 1C3W with [Bacteriorhodopsin]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:06:30 2008

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