2wy3: Difference between revisions

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<StructureSection load='2wy3' size='340' side='right'caption='[[2wy3]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2wy3' size='340' side='right'caption='[[2wy3]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2wy3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hcmva Hcmva] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WY3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WY3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2wy3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hcmva Hcmva] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WY3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEU:2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL'>PEU</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEU:2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL'>PEU</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1je6|1je6]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1je6|1je6]]</div></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wy3 OCA], [http://pdbe.org/2wy3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wy3 RCSB], [http://www.ebi.ac.uk/pdbsum/2wy3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wy3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wy3 OCA], [https://pdbe.org/2wy3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wy3 RCSB], [https://www.ebi.ac.uk/pdbsum/2wy3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wy3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/UL16P_HCMVA UL16P_HCMVA]] Plays a role in escape from host immune response. Blocks the interaction between the host NKG2D receptor with the ligands ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. The sequestration of diverse NKG2D ligands in the endoplasmic reticulum and cis-Golgi apparatus of cells by UL16 inhibits the activation of NK cells.<ref>PMID:12847260</ref> <ref>PMID:12782710</ref>   
[[https://www.uniprot.org/uniprot/UL16P_HCMVA UL16P_HCMVA]] Plays a role in escape from host immune response. Blocks the interaction between the host NKG2D receptor with the ligands ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. The sequestration of diverse NKG2D ligands in the endoplasmic reticulum and cis-Golgi apparatus of cells by UL16 inhibits the activation of NK cells.<ref>PMID:12847260</ref> <ref>PMID:12782710</ref>   
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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