2xg8: Difference between revisions

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<StructureSection load='2xg8' size='340' side='right'caption='[[2xg8]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='2xg8' size='340' side='right'caption='[[2xg8]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xg8]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Anacystis_nidulans_r2 Anacystis nidulans r2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XG8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XG8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2xg8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Anacystis_nidulans_r2 Anacystis nidulans r2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XG8 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qy7|1qy7]], [[2jj4|2jj4]], [[2xbp|2xbp]], [[2v5h|2v5h]], [[2xko|2xko]]</td></tr>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qy7|1qy7]], [[2jj4|2jj4]], [[2xbp|2xbp]], [[2v5h|2v5h]], [[2xko|2xko]]</div></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xg8 OCA], [http://pdbe.org/2xg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xg8 RCSB], [http://www.ebi.ac.uk/pdbsum/2xg8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xg8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xg8 OCA], [https://pdbe.org/2xg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xg8 RCSB], [https://www.ebi.ac.uk/pdbsum/2xg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xg8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GLNB_SYNE7 GLNB_SYNE7]] P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is phosphorylated, these events are reversed. In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is phosphorylated which allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme.  
[[https://www.uniprot.org/uniprot/GLNB_SYNE7 GLNB_SYNE7]] P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is phosphorylated, these events are reversed. In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is phosphorylated which allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme.  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]