1c5f: Difference between revisions

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[[Image:1c5f.gif|left|200px]]
{{Seed}}
[[Image:1c5f.png|left|200px]]


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{{STRUCTURE_1c5f|  PDB=1c5f  |  SCENE=  }}  
{{STRUCTURE_1c5f|  PDB=1c5f  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF THE CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI COMPLEXED WITH CYCLOSPORIN A'''
===CRYSTAL STRUCTURE OF THE CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI COMPLEXED WITH CYCLOSPORIN A===




==Overview==
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The resistance of the human parasite Brugia malayi to the antiparasitic activity of cyclosporin A (CsA) may arise from the presence of cyclophilins with relatively low affinity for the drug. The structure of the complex of B. malayi cyclophilin (BmCYP-1) and CsA, with eight independent copies in the asymmetric unit, has been determined at a resolution of 2.7 A. The low affinity of BmCYP-1 for CsA arises from incomplete preorganization of the binding site so that the formation of a hydrogen bond between His132 of BmCYP-1 and N-methylleucine 9 of CsA is associated with a shift in the backbone of approximately 1 A in this region.
The line below this paragraph, {{ABSTRACT_PUBMED_10642184}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_10642184}}


==About this Structure==
==About this Structure==
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[[Category: Peptidyl-prolyl cis-tran]]
[[Category: Peptidyl-prolyl cis-tran]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Peptidylprolyl isomerase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:21:00 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:14:07 2008''
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