1c6w: Difference between revisions

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[[Image:1c6w.~~jpg~~|left|200px]]

[[Image:1c6w.png|left|200px]]

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~~'''~~MAUROCALCIN FROM SCORPIO MAURUS~~'''~~

===MAUROCALCIN FROM SCORPIO MAURUS===

~~==Overview==~~

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~~We determined~~ the ~~structure in solution by (1)H two-dimensional NMR of Maurocalcine from the venom of Scorpio maurus. This toxin has been demonstrated~~ to ~~be a potent effector of ryanodyne-sensitive calcium channel from skeletal muscles. This is~~ the ~~first description of a scorpion toxin which folds following the Inhibitor Cystine Knot fold~~ (~~ICK) already described for numerous toxic and inhibitory peptides,~~ as ~~well as for various protease inhibitors. Its three dimensional structure consists of a compact disulfide-bonded core from which emerge loops and the N-terminus~~. ~~A double-stranded antiparallel beta-sheet comprises residues 20-23 and 30-33~~. ~~A third extended strand (residues 9-11~~) is ~~perpendicular to~~ the ~~beta-sheet~~. ~~Maurocalcine structure mimics the activating segment of the dihydropyridine receptor II~~-~~III loop and is therefore potentially useful for dihydropyridine receptor/ryanodine receptor interaction studies. Proteins 2000;40:436~~-~~442.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10861934}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10861934 is the PubMed ID number.

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==About this Structure==

Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C6W OCA].

Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C6W OCA].

==Reference==

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[[Category: Ryanodine receptor effector]]

[[Category: Scorpion toxin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 12~~:24:09 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:17:51 2008''

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-[[Image:1c6w.jpg|left|200px]]
+{{Seed}}
+[[Image:1c6w.png|left|200px]]
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 {{STRUCTURE_1c6w|  PDB=1c6w  |  SCENE=  }}
-'''MAUROCALCIN FROM SCORPIO MAURUS'''
+===MAUROCALCIN FROM SCORPIO MAURUS===
-==Overview==
+<!--
-We determined the structure in solution by (1)H two-dimensional NMR of Maurocalcine from the venom of Scorpio maurus. This toxin has been demonstrated to be a potent effector of ryanodyne-sensitive calcium channel from skeletal muscles. This is the first description of a scorpion toxin which folds following the Inhibitor Cystine Knot fold (ICK) already described for numerous toxic and inhibitory peptides, as well as for various protease inhibitors. Its three dimensional structure consists of a compact disulfide-bonded core from which emerge loops and the N-terminus. A double-stranded antiparallel beta-sheet comprises residues 20-23 and 30-33. A third extended strand (residues 9-11) is perpendicular to the beta-sheet. Maurocalcine structure mimics the activating segment of the dihydropyridine receptor II-III loop and is therefore potentially useful for dihydropyridine receptor/ryanodine receptor interaction studies. Proteins 2000;40:436-442.
+The line below this paragraph, {{ABSTRACT_PUBMED_10861934}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10861934 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10861934}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C6W OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C6W OCA].
 ==Reference==
@@ Line 30: / Line 34: @@
 [[Category: Ryanodine receptor effector]]
 [[Category: Scorpion toxin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:24:09 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:17:51 2008''