1c7b: Difference between revisions

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[[Image:1c7b.gif|left|200px]]
{{Seed}}
[[Image:1c7b.png|left|200px]]


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{{STRUCTURE_1c7b|  PDB=1c7b  |  SCENE=  }}  
{{STRUCTURE_1c7b|  PDB=1c7b  |  SCENE=  }}  


'''DEOXY RHB1.0 (RECOMBINANT HEMOGLOBIN)'''
===DEOXY RHB1.0 (RECOMBINANT HEMOGLOBIN)===




==Overview==
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The crystal structures of three recombinant human hemoglobins, rHb1. 0, rHb1.1 and rHb1.2, have been determined in the deoxy state at 1.8 A resolution. Two of the three proteins, rHb1.1 and rHb1.2, contain a genetic fusion of the alpha subunits, a one- or two-glycine link, respectively, whereas rHb1.0 does not. The glycine crosslinks, localized between one N- and C--termini pair of the alpha subunits in the deoxy crystalline state, do not perturb the overall tertiary or quaternary or even the local structure of hemoglobin. Therefore, genetic fusion to prevent the dissociation of the hemoglobin tetramer, thereby inhibiting renal clearance based upon molecular size, is a structurally conservative method to stabilize hemoglobin for use as an oxygen-delivery therapeutic.
The line below this paragraph, {{ABSTRACT_PUBMED_10930828}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10930828 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10930828}}


==About this Structure==
==About this Structure==
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[[Category: Heme]]
[[Category: Heme]]
[[Category: Oxygen delivery vehicle]]
[[Category: Oxygen delivery vehicle]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:24:53 2008''
 
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