6rv2: Difference between revisions

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<StructureSection load='6rv2' size='340' side='right'caption='[[6rv2]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='6rv2' size='340' side='right'caption='[[6rv2]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6rv2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RV2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RV2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6rv2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RV2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KCNK3, TASK, TASK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rv2 OCA], [http://pdbe.org/6rv2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rv2 RCSB], [http://www.ebi.ac.uk/pdbsum/6rv2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rv2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rv2 OCA], [https://pdbe.org/6rv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rv2 RCSB], [https://www.ebi.ac.uk/pdbsum/6rv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rv2 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/KCNK3_HUMAN KCNK3_HUMAN]] Heritable pulmonary arterial hypertension. The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/KCNK3_HUMAN KCNK3_HUMAN] Heritable pulmonary arterial hypertension. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KCNK3_HUMAN KCNK3_HUMAN]] pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.<ref>PMID:23169818</ref> <ref>PMID:9312005</ref>
[https://www.uniprot.org/uniprot/KCNK3_HUMAN KCNK3_HUMAN] pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.<ref>PMID:23169818</ref> <ref>PMID:9312005</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Burgess-Brown, N]]
[[Category: Burgess-Brown N]]
[[Category: Bushell, S R]]
[[Category: Bushell SR]]
[[Category: Carpenter, E P]]
[[Category: Carpenter EP]]
[[Category: Chalk, R]]
[[Category: Chalk R]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: Mukhopadhyay, S M.M]]
[[Category: Mukhopadhyay SMM]]
[[Category: Pike, A C.W]]
[[Category: Pike ACW]]
[[Category: Quigley, A]]
[[Category: Quigley A]]
[[Category: Rodstrom, K E.J]]
[[Category: Rodstrom KEJ]]
[[Category: Structural genomic]]
[[Category: Shrestha L]]
[[Category: Shrestha, L]]
[[Category: Speedman D]]
[[Category: Speedman, D]]
[[Category: Tessitore A]]
[[Category: Tessitore, A]]
[[Category: Venkaya S]]
[[Category: Venkaya, S]]
[[Category: Zhang W]]
[[Category: Zhang, W]]
[[Category: Membrane protein]]
[[Category: Potassium channel]]
[[Category: Sgc]]
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