1c8a: Difference between revisions

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[[Image:1c8a.gif|left|200px]]
{{Seed}}
[[Image:1c8a.png|left|200px]]


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{{STRUCTURE_1c8a|  PDB=1c8a  |  SCENE=  }}  
{{STRUCTURE_1c8a|  PDB=1c8a  |  SCENE=  }}  


'''NMR STRUCTURE OF INTRAMOLECULAR DIMER ANTIFREEZE PROTEIN RD3, 40 SA STRUCTURES'''
===NMR STRUCTURE OF INTRAMOLECULAR DIMER ANTIFREEZE PROTEIN RD3, 40 SA STRUCTURES===




==Overview==
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The structure of a new antifreeze protein (AFP) variant, RD3, from antarctic eel pout (Rhigophila dearborni) with enhanced activity has been determined for the first time by nuclear magnetic resonance spectroscopy. RD3 comprises a unique translational topology of two homologous type III AFP globular domains, each containing one flat, ice binding plane. The ice binding plane of the N domain is located approximately 3.5 A "behind" that of the C domain. The two ice binding planes are located laterally with an angle of 32 +/- 12 degrees between the planes. These results suggest that the C domain plane of RD3 binds first to the ice [1010] prism plane in the &lt;0001&gt; direction, which induces successive ice binding of the N domain in the &lt;0101&gt; direction. This manner of ice binding caused by the unique structural topology of RD3 is thought to be crucial for the significant enhancement of antifreeze activity, especially at low AFP concentrations.
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{{ABSTRACT_PUBMED_11010977}}


==About this Structure==
==About this Structure==
1C8A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pachycara_brachycephalum Pachycara brachycephalum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C8A OCA].  
1C8A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pachycara_brachycephalum Pachycara brachycephalum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C8A OCA].  


==Reference==
==Reference==
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[[Category: Ice binding protein]]
[[Category: Ice binding protein]]
[[Category: Thermal hysteresis protein]]
[[Category: Thermal hysteresis protein]]
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