2yjz: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[2yjz]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2YJZ FirstGlance]. <br>

<table><tr><td colspan='2'>[[2yjz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YJZ FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2yjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yjz OCA], [~~http~~://pdbe.org/2yjz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2yjz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2yjz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2yjz ProSAT]</span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yjz OCA], [https://pdbe.org/2yjz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yjz RCSB], [https://www.ebi.ac.uk/pdbsum/2yjz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yjz ProSAT]</span></td></tr>

</table>

== Function ==

[[~~http~~://www.uniprot.org/uniprot/STEA4_RAT STEA4_RAT]] Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Inhibits anchorage-independent cell proliferation. Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Play a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity).

[[https://www.uniprot.org/uniprot/STEA4_RAT STEA4_RAT]] Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Inhibits anchorage-independent cell proliferation. Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Play a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity).

== Publication Abstract from PubMed ==

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 <StructureSection load='2yjz' size='340' side='right'caption='[[2yjz]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2yjz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YJZ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2yjz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YJZ FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2yjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yjz OCA], [http://pdbe.org/2yjz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yjz RCSB], [http://www.ebi.ac.uk/pdbsum/2yjz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yjz ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yjz OCA], [https://pdbe.org/2yjz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yjz RCSB], [https://www.ebi.ac.uk/pdbsum/2yjz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yjz ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/STEA4_RAT STEA4_RAT]] Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Inhibits anchorage-independent cell proliferation. Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Play a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity).
+[[https://www.uniprot.org/uniprot/STEA4_RAT STEA4_RAT]] Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Inhibits anchorage-independent cell proliferation. Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Play a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity).
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==