Sandbox 20005: Difference between revisions
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There’s a new [http://go.usa.gov/xw9MV NCBI site] on COVID-19/SARS-CoV-2. It will help bench scientists, bioinformaticians, clinicians & others connect with information they need to study SARS-CoV-2 and end the pandemic. | There’s a new [http://go.usa.gov/xw9MV NCBI site] on COVID-19/SARS-CoV-2. It will help bench scientists, bioinformaticians, clinicians & others connect with information they need to study SARS-CoV-2 and end the pandemic. | ||
A [http://youtu.be/hwVl_-lnoys '''''video'''''] (by [http://elarasystems.com Elara)] shows how the virus [http://youtu.be/hwVl_-lnoys '''interacts with its human (host) cells'''], via its ''spikes'' (3D structure determined in the McLellan Lab (U of Texas, Austin)<ref name="McLellan">PMID:32075877</ref>)) and Wrobel, Benton & Gamblin labs <ref name="wrobel">PMID: 32647346</ref> (Crick Institute, London), thus permitting the viral genome to enter its host & begin infection. | A [http://youtu.be/hwVl_-lnoys '''''video'''''] (by [http://elarasystems.com Elara)] shows how the virus [http://youtu.be/hwVl_-lnoys '''interacts with its human (host) cells'''], via its ''spikes'' (3D structure determined in the McLellan Lab (U of Texas, Austin)<ref name="McLellan">PMID:32075877</ref>)) and Wrobel, Benton & Gamblin labs <ref name="wrobel">PMID: 32647346</ref> (Crick Institute, London), thus permitting the viral genome to enter its host & begin infection. An shows the priming of the spike protein for optimal binding, induced when the spike is clipped by a protease on the right and [[SARS-CoV-2 protein S priming by furin|'''more information''']]. | ||
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== Potential treatments for COVID-19 == | == Potential treatments for COVID-19 == | ||
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* A team of US and Chinese scientists determined the crystal structure of '''2019-nCoV spike receptor-binding domain bound with ACE2''' [[6m0j]] | * A team of US and Chinese scientists determined the crystal structure of '''2019-nCoV spike receptor-binding domain bound with ACE2''' [[6m0j]] | ||
* A team of US scientists determined, by Cryo-EM, the '''structure of the SARS-CoV-2 spike glycoprotein (open & closed states)''' <ref>PMID:32155444</ref>, PDB-ID [[6vxx]] and [[6vyb]] | * A team of US scientists determined, by Cryo-EM, the '''structure of the SARS-CoV-2 spike glycoprotein (open & closed states)''' <ref>PMID:32155444</ref>, PDB-ID [[6vxx]] and [[6vyb]]. See an [[SARS-CoV-2 protein S priming by furin|animation of this transition]]. | ||
* Crystal structure of SARS-CoV-2 receptor binding domain in complex with human antibody CR3022 [[6w41]] | * Crystal structure of SARS-CoV-2 receptor binding domain in complex with human antibody CR3022 [[6w41]] | ||
