1c8z: Difference between revisions

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[[Image:1c8z.gif|left|200px]]
{{Seed}}
[[Image:1c8z.png|left|200px]]


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{{STRUCTURE_1c8z|  PDB=1c8z  |  SCENE=  }}  
{{STRUCTURE_1c8z|  PDB=1c8z  |  SCENE=  }}  


'''C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN'''
===C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN===




==Overview==
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Tubby-like proteins (TULPs) are found in a broad range of multicellular organisms. In mammals, genetic mutation of tubby or other TULPs can result in one or more of three disease phenotypes: obesity (from which the name "tubby" is derived), retinal degeneration, and hearing loss. These disease phenotypes indicate a vital role for tubby proteins; however, no biochemical function has yet been ascribed to any member of this protein family. A structure-directed approach was employed to investigate the biological function of these proteins. The crystal structure of the core domain from mouse tubby was determined at a resolution of 1.9 angstroms. From primarily structural clues, experiments were devised, the results of which suggest that TULPs are a unique family of bipartite transcription factors.
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{{ABSTRACT_PUBMED_10591637}}


==About this Structure==
==About this Structure==
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[[Category: Obesity blindness]]
[[Category: Obesity blindness]]
[[Category: Tubby filled-barrel]]
[[Category: Tubby filled-barrel]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:28:38 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:23:08 2008''

Revision as of 17:23, 30 June 2008

File:1c8z.png

Template:STRUCTURE 1c8z

C-TERMINAL DOMAIN OF MOUSE BRAIN TUBBY PROTEIN

Template:ABSTRACT PUBMED 10591637

About this Structure

1C8Z is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Implication of tubby proteins as transcription factors by structure-based functional analysis., Boggon TJ, Shan WS, Santagata S, Myers SC, Shapiro L, Science. 1999 Dec 10;286(5447):2119-25. PMID:10591637

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