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==Structure of human Cathepsin K with an ectosteric inhibitor at 1.85 Angstrom resolution==
==Structure of human Cathepsin K with an ectosteric inhibitor at 1.85 Angstrom resolution==
<StructureSection load='6pxf' size='340' side='right'caption='[[6pxf]]' scene=''>
<StructureSection load='6pxf' size='340' side='right'caption='[[6pxf]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PXF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6PXF FirstGlance]. <br>
<table><tr><td colspan='2'>[[6pxf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PXF FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6pxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pxf OCA], [http://pdbe.org/6pxf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pxf RCSB], [http://www.ebi.ac.uk/pdbsum/6pxf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pxf ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=J0V:1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-sulfonic+acid'>J0V</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pxf OCA], [https://pdbe.org/6pxf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pxf RCSB], [https://www.ebi.ac.uk/pdbsum/6pxf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pxf ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[https://omim.org/entry/265800 265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref>
== Function ==
[https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
==See Also==
*[[Cathepsin 3D structures|Cathepsin 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Aguda AH]]
[[Category: Aguda AH]]
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