6zed: Difference between revisions
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==CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX with compound F1== | ==CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX with compound F1== | ||
<StructureSection load='6zed' size='340' side='right'caption='[[6zed]]' scene=''> | <StructureSection load='6zed' size='340' side='right'caption='[[6zed]], [[Resolution|resolution]] 1.08Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZED OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6zed]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZED OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZED FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=QGN:4,5-dimethyl-1~{H}-pyrazolo[3,4-c]pyridazin-3-amine'>QGN</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zed FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zed OCA], [https://pdbe.org/6zed PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zed RCSB], [https://www.ebi.ac.uk/pdbsum/6zed PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zed ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
==See Also== | |||
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith, C H]] | ||
[[Category: Barril X]] | [[Category: Barril, X]] | ||
[[Category: Bountra C]] | [[Category: Bountra, C]] | ||
[[Category: Edwards | [[Category: Delft, F von]] | ||
[[Category: Filippakopoulos P]] | [[Category: Edwards, A M]] | ||
[[Category: Krojer T]] | [[Category: Filippakopoulos, P]] | ||
[[Category: Martinez-Cartro M]] | [[Category: Krojer, T]] | ||
[[Category: Picaud S]] | [[Category: Martinez-Cartro, M]] | ||
[[Category: | [[Category: Picaud, S]] | ||
[[Category: Structural genomic]] | |||
[[Category: Brd4]] | |||
[[Category: Bromodomain-containing protein 4]] | |||
[[Category: Bromodomain-containing protein 4 isoform long]] | |||
[[Category: Cap]] | |||
[[Category: Cell cycle]] | |||
[[Category: Hunk1]] | |||
[[Category: Mcap]] | |||
[[Category: Mitotic chromosome associated protein]] | |||
[[Category: Sgc]] | |||
