3cis: Difference between revisions
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<StructureSection load='3cis' size='340' side='right'caption='[[3cis]], [[Resolution|resolution]] 2.90Å' scene=''> | <StructureSection load='3cis' size='340' side='right'caption='[[3cis]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3cis]] is a 8 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3cis]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CIS FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cis OCA], [https://pdbe.org/3cis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cis RCSB], [https://www.ebi.ac.uk/pdbsum/3cis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cis ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/Y2623_MYCTU Y2623_MYCTU] May play a role in the establishment of a persistent infection (latency) in the host, as strains without this gene are hypervirulent. Overexpression of the protein retards growth in culture; Glu-15 and Ala-117 mutant proteins which bind less ATP do not show this retardation, suggesting growth may be regulated through an ATP-dependent function. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Almo | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Bilder | [[Category: Almo SC]] | ||
[[Category: Chan | [[Category: Bilder P]] | ||
[[Category: Drumm | [[Category: Chan J]] | ||
[[Category: Mi | [[Category: Drumm J]] | ||
[[Category: Mi K]] | |||
Latest revision as of 12:29, 30 August 2023
The Crystal Structure of Rv2623 from Mycobacterium tuberculosis
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