2z8n: Difference between revisions

<table><tr><td colspan='2'>[[2z8n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8N OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2Z8N FirstGlance]. <br>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2z8m|2z8m]], [[2z8o|2z8o]], [[2z8p|2z8p]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2z8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z8n OCA], [http://pdbe.org/2z8n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2z8n RCSB], [http://www.ebi.ac.uk/pdbsum/2z8n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2z8n ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/SPVC_SALTY SPVC_SALTY]] Secreted effector that irreversibly inactivates host MAP kinases by catalyzing the dephosphorylation of the phosphothreonine residue in the pT-X-pY motif in MAPK2/ERK2, MAPK3/ERK1, and p38, via a beta-elimination reaction leading to a dehydrobutyrine residue. Is also able to remove the phosphate group from phospho-JNK in vitro, but JNK may not be a substrate in vivo. Could help suppress localized proinflammatory responses at infection foci in the spleen and liver, and thereby facilitate bacterial growth.<ref>PMID:17303758</ref> <ref>PMID:18060821</ref> <ref>PMID:18084305</ref> <ref>PMID:18284579</ref>