1ca6: Difference between revisions

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[[Image:1ca6.gif|left|200px]]
{{Seed}}
[[Image:1ca6.png|left|200px]]


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{{STRUCTURE_1ca6|  PDB=1ca6  |  SCENE=  }}  
{{STRUCTURE_1ca6|  PDB=1ca6  |  SCENE=  }}  


'''INTERCALATION SITE OF HYPERTHERMOPHILE CHROMOSOMAL PROTEIN SSO7D/SAC7D BOUND TO DNA'''
===INTERCALATION SITE OF HYPERTHERMOPHILE CHROMOSOMAL PROTEIN SSO7D/SAC7D BOUND TO DNA===




==Overview==
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Sso7d and Sac7d are two small chromatin proteins from the hyperthermophilic archaeabacterium Sulfolobus solfataricus and Sulfolobus acidocaldarius, respectively. The crystal structures of Sso7d-GTGATCGC, Sac7d-GTGATCGC and Sac7d-GTGATCAC have been determined and refined at 1.45 A, 2.2 A and 2.2 A, respectively, to investigate the DNA binding property of Sso7d/Sac7d in the presence of a T-G mismatch base-pair. Detailed structural analysis revealed that the intercalation site includes the T-G mismatch base-pair and Sso7d/Sac7d bind to that mismatch base-pair in a manner similar to regular DNA. In the Sso7d-GTGATCGC complex, a new inter-strand hydrogen bond between T2O4 and C14N4 is formed and well-order bridging water molecules are found. The results suggest that the less stable DNA stacking site involving a T-G mismatch may be a preferred site for protein side-chain intercalation.
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{{ABSTRACT_PUBMED_11031116}}


==About this Structure==
==About this Structure==
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[[Category: Sac7d]]
[[Category: Sac7d]]
[[Category: Sso7d]]
[[Category: Sso7d]]
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