5l8a: Difference between revisions
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<StructureSection load='5l8a' size='340' side='right'caption='[[5l8a]], [[Resolution|resolution]] 1.57Å' scene=''> | <StructureSection load='5l8a' size='340' side='right'caption='[[5l8a]], [[Resolution|resolution]] 1.57Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5l8a]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5l8a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L8A FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6RB:1-(2-HYDROXYETHYL)-5-[(4-METHOXYNAPHTHALEN-1-YL)METHYL]-~{N}-(PHENYLMETHYL)-6,7-DIHYDRO-4~{H}-PYRAZOLO[4,3-C]PYRIDINE-3-CARBOXAMIDE'>6RB</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6RB:1-(2-HYDROXYETHYL)-5-[(4-METHOXYNAPHTHALEN-1-YL)METHYL]-~{N}-(PHENYLMETHYL)-6,7-DIHYDRO-4~{H}-PYRAZOLO[4,3-C]PYRIDINE-3-CARBOXAMIDE'>6RB</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l8a OCA], [https://pdbe.org/5l8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l8a RCSB], [https://www.ebi.ac.uk/pdbsum/5l8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l8a ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/Q8IEW2_TRYBB Q8IEW2_TRYBB] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Trypanosoma brucei brucei]] | ||
[[Category: Dawidowski | [[Category: Dawidowski M]] | ||
[[Category: Emmanouilidis | [[Category: Emmanouilidis L]] | ||
[[Category: Popowicz | [[Category: Popowicz GM]] | ||
[[Category: Sattler | [[Category: Sattler M]] | ||
Latest revision as of 16:10, 4 October 2023
Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases.
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