5lfq: Difference between revisions

<table><tr><td colspan='2'>[[5lfq]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LFQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LFQ FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.503&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lfq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lfq OCA], [https://pdbe.org/5lfq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lfq RCSB], [https://www.ebi.ac.uk/pdbsum/5lfq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lfq ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/BPA_MYCTU BPA_MYCTU] Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction. Can inhibit degradation of Pup-tagged substrates in vitro by competing with Mpa for association with the proteasome.<ref>PMID:25469515</ref>  

[[Category: Mycobacterium tuberculosis H37Rv]]

[[Category: Ban N]]

[[Category: Boehringer D]]

[[Category: Bolten M]]

[[Category: Delley CL]]

[[Category: Leibundgut M]]

[[Category: Weber-Ban E]]