6pxe: Difference between revisions

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<StructureSection load='6pxe' size='340' side='right'caption='[[6pxe]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='6pxe' size='340' side='right'caption='[[6pxe]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6pxe]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpt4 Bpt4] and [http://en.wikipedia.org/wiki/Escherichia_phage_vb_ecom_nbg2 Escherichia phage vb_ecom_nbg2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PXE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6PXE FirstGlance]. <br>
<table><tr><td colspan='2'>[[6pxe]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_vB_EcoM_NBG2 Escherichia phage vB_EcoM_NBG2] and [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PXE FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rI, 58.6, rIA, tk.-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10665 BPT4]), vBEcoMNBG2_239 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2184699 Escherichia phage vB_EcoM_NBG2])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6pxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pxe OCA], [http://pdbe.org/6pxe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pxe RCSB], [http://www.ebi.ac.uk/pdbsum/6pxe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pxe ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pxe OCA], [https://pdbe.org/6pxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pxe RCSB], [https://www.ebi.ac.uk/pdbsum/6pxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pxe ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ANTIH_BPT4 ANTIH_BPT4]] Involved in lysis inhibition. Interacts with and inhibits the holin thereby delaying the host cell lysis timing. Lysis inhibition is imposed when a cell infected by a T4-like virus is superinfected by new incoming viruses. This is probably due to the capsid content of the new phage being released in the periplasm because of blockage of entry due to superinfection exclusion. These periplasmically released viral proteins must somehow activate the periplasmic antiholin, which in turn will block the holin multimerization.[HAMAP-Rule:MF_04105]<ref>PMID:17693511</ref> <ref>PMID:22389108</ref> <ref>PMID:9560373</ref> [[http://www.uniprot.org/uniprot/A0A2U8QQK7_9CAUD A0A2U8QQK7_9CAUD]] Accumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of micron-scale pores (holes) causing host cell membrane disruption and endolysin escape into the periplasmic space. Determines the precise timing of host cell lysis. Participates with the endolysin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles from the host cell.[HAMAP-Rule:MF_04104]
[https://www.uniprot.org/uniprot/ANTIH_BPT4 ANTIH_BPT4] Involved in lysis inhibition. Interacts with and inhibits the holin thereby delaying the host cell lysis timing. Lysis inhibition is imposed when a cell infected by a T4-like virus is superinfected by new incoming viruses. This is probably due to the capsid content of the new phage being released in the periplasm because of blockage of entry due to superinfection exclusion. These periplasmically released viral proteins must somehow activate the periplasmic antiholin, which in turn will block the holin multimerization.[HAMAP-Rule:MF_04105]<ref>PMID:17693511</ref> <ref>PMID:22389108</ref> <ref>PMID:9560373</ref>  
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bpt4]]
[[Category: Escherichia phage vB_EcoM_NBG2]]
[[Category: Escherichia phage vb_ecom_nbg2]]
[[Category: Escherichia virus T4]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Krieger, I V]]
[[Category: Krieger IV]]
[[Category: Sacchettini, J C]]
[[Category: Sacchettini JC]]
[[Category: Lysis inhibition]]
[[Category: Phage]]
[[Category: Viral protein]]
Retrieved from "https://proteopedia.org/6pxe"