6vxw: Difference between revisions

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==NMR solution structure of natural scorpion toxin Cl13==
==NMR solution structure of natural scorpion toxin Cl13==
<StructureSection load='6vxw' size='340' side='right'caption='[[6vxw]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='6vxw' size='340' side='right'caption='[[6vxw]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6vxw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Centruroides_limpidus Centruroides limpidus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VXW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VXW FirstGlance]. <br>
<table><tr><td colspan='2'>[[6vxw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Centruroides_limpidus Centruroides limpidus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VXW FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vxw OCA], [http://pdbe.org/6vxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vxw RCSB], [http://www.ebi.ac.uk/pdbsum/6vxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vxw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vxw OCA], [https://pdbe.org/6vxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vxw RCSB], [https://www.ebi.ac.uk/pdbsum/6vxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vxw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SCXD_CENLI SCXD_CENLI] Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity). Inhibits sodium channels Nav1.4/SCN4A, Nav1.5/SCN5A and Nav1.6/SCN8A (PubMed:27871874). Also has a weak inhibitory effect on Nav1.2/SCN2A (PubMed:27871874). Is lethal to mice (PubMed:27871874).[UniProtKB:P60266]<ref>PMID:27871874</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Centruroides limpidus]]
[[Category: Centruroides limpidus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Delepierre, M]]
[[Category: Delepierre M]]
[[Category: Giraldo, A E.Lopez]]
[[Category: Lopez Giraldo AE]]
[[Category: Portilla, F del Rio]]
[[Category: Del Rio Portilla F]]
[[Category: Sodium beta toxin]]
[[Category: Toxin]]
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