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==Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor ZL0590==
==Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor ZL0590==
<StructureSection load='6u0d' size='340' side='right'caption='[[6u0d]]' scene=''>
<StructureSection load='6u0d' size='340' side='right'caption='[[6u0d]], [[Resolution|resolution]] 1.43&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U0D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6U0D FirstGlance]. <br>
<table><tr><td colspan='2'>[[6u0d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U0D FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6u0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u0d OCA], [http://pdbe.org/6u0d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u0d RCSB], [http://www.ebi.ac.uk/pdbsum/6u0d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u0d ProSAT]</span></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=POJ:N-[4-({(2S)-2-[(morpholin-4-yl)methyl]pyrrolidin-1-yl}sulfonyl)phenyl]-N-[4-(trifluoromethyl)phenyl]urea'>POJ</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u0d OCA], [https://pdbe.org/6u0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u0d RCSB], [https://www.ebi.ac.uk/pdbsum/6u0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u0d ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> 
== Function ==
[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
==See Also==
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Joseph S]]
[[Category: Joseph, S]]
[[Category: Leonard PG]]
[[Category: Leonard, P G]]
[[Category: Bromodomain]]
[[Category: Complex]]
[[Category: Gene regulation]]
[[Category: Inhibitor]]
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