1cfa: Difference between revisions

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[[Image:1cfa.gif|left|200px]]
{{Seed}}
[[Image:1cfa.png|left|200px]]


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{{STRUCTURE_1cfa|  PDB=1cfa  |  SCENE=  }}  
{{STRUCTURE_1cfa|  PDB=1cfa  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF A SEMI-SYNTHETIC C5A RECEPTOR ANTAGONIST AT PH 5.2, 303K, NMR, 20 STRUCTURES'''
===SOLUTION STRUCTURE OF A SEMI-SYNTHETIC C5A RECEPTOR ANTAGONIST AT PH 5.2, 303K, NMR, 20 STRUCTURES===




==Overview==
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The tertiary structure of a unique C5a receptor antagonist was determined by two-dimensional NMR spectroscopy. The core domain of this 8-kDa antagonist exists as an antiparallel helical bundle, similar to recombinant human (rh)-C5a. However, unlike C5a, the antagonist's C terminus was found to be conformationally restricted along a groove between helices one and four in the core domain. This conformational restriction situates C-terminal D-Arg 75 in a wedge between core residues Arg 46 and His 15. Correlation of the antagonist's tertiary structure with point mutation analysis revealed the formation of a positively charged contiguous contact surface comprised of D-Arg 75, Arg 46, Lys 49, and His 15. The significance of this surface in generating antagonist properties implies a single binding site with the C5a receptor and provides a structural template for drug design.
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{{ABSTRACT_PUBMED_9007977}}


==About this Structure==
==About this Structure==
1CFA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CFA OCA].  
1CFA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CFA OCA].  


==Reference==
==Reference==
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[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
[[Category: Gp antagonist]]
[[Category: Gp antagonist]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:40:17 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:40:10 2008''
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