1cfc: Difference between revisions

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[[Image:1cfc.gif|left|200px]]
{{Seed}}
[[Image:1cfc.png|left|200px]]


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{{STRUCTURE_1cfc|  PDB=1cfc  |  SCENE=  }}  
{{STRUCTURE_1cfc|  PDB=1cfc  |  SCENE=  }}  


'''CALCIUM-FREE CALMODULIN'''
===CALCIUM-FREE CALMODULIN===




==Overview==
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The three-dimensional structure of calmodulin in the absence of Ca2+ has been determined by three- and four-dimensional heteronuclear NMR experiments, including ROE, isotope-filtering combined with reverse labelling, and measurement of more than 700 three-bond J-couplings. In analogy with the Ca(2+)-ligated state of this protein, it consists of two small globular domains separated by a flexible linker, with no stable, direct contacts between the two domains. In the absence of Ca2+, the four helices in each of the two globular domains form a highly twisted bundle, capped by a short anti-parallel beta-sheet. This arrangement is qualitatively similar to that observed in the crystal structure of the Ca(2+)-free N-terminal domain of troponin C.
The line below this paragraph, {{ABSTRACT_PUBMED_7552748}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 7552748 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7552748}}


==About this Structure==
==About this Structure==
1CFC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CFC OCA].  
1CFC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CFC OCA].  


==Reference==
==Reference==
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[[Category: Tjandra, N.]]
[[Category: Tjandra, N.]]
[[Category: Calcium-binding protein]]
[[Category: Calcium-binding protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:40:28 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 20:40:24 2008''

Revision as of 17:40, 30 June 2008

File:1cfc.png


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1cfc, 25 NMR models (default scene)
Related: 1cfd
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



CALCIUM-FREE CALMODULIN

Template:ABSTRACT PUBMED 7552748

About this Structure

1CFC is a Single protein structure of sequence from Xenopus laevis. Full experimental information is available from OCA.

Reference

Solution structure of calcium-free calmodulin., Kuboniwa H, Tjandra N, Grzesiek S, Ren H, Klee CB, Bax A, Nat Struct Biol. 1995 Sep;2(9):768-76. PMID:7552748

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