1cfd: Difference between revisions

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[[Image:1cfd.gif|left|200px]]
[[Image:1cfd.png|left|200px]]


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==Overview==
{{ABSTRACT_7552748}}
The three-dimensional structure of calmodulin in the absence of Ca2+ has been determined by three- and four-dimensional heteronuclear NMR experiments, including ROE, isotope-filtering combined with reverse labelling, and measurement of more than 700 three-bond J-couplings. In analogy with the Ca(2+)-ligated state of this protein, it consists of two small globular domains separated by a flexible linker, with no stable, direct contacts between the two domains. In the absence of Ca2+, the four helices in each of the two globular domains form a highly twisted bundle, capped by a short anti-parallel beta-sheet. This arrangement is qualitatively similar to that observed in the crystal structure of the Ca(2+)-free N-terminal domain of troponin C.


==About this Structure==
==About this Structure==
1CFD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. The following page contains interesting information on the relation of 1CFD with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb44_1.html Calmodulin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CFD OCA].  
1CFD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. The following page contains interesting information on the relation of 1CFD with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb44_1.html Calmodulin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CFD OCA].  
==Reference==
Solution structure of calcium-free calmodulin., Kuboniwa H, Tjandra N, Grzesiek S, Ren H, Klee CB, Bax A, Nat Struct Biol. 1995 Sep;2(9):768-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7552748 7552748]
[[Category: Calmodulin]]
[[Category: Calmodulin]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Tjandra, N.]]
[[Category: Tjandra, N.]]
[[Category: Calcium-binding protein]]
[[Category: Calcium-binding protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:40:29 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:07:58 2008''

Revision as of 14:07, 26 June 2008

File:1cfd.png

Template:STRUCTURE 1cfd

CALCIUM-FREE CALMODULIN


Template:ABSTRACT 7552748

About this Structure

1CFD is a Single protein structure of sequence from Xenopus laevis. The following page contains interesting information on the relation of 1CFD with [Calmodulin]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:07:58 2008

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