5m7u: Difference between revisions

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<StructureSection load='5m7u' size='340' side='right'caption='[[5m7u]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='5m7u' size='340' side='right'caption='[[5m7u]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5m7u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M7U OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5M7U FirstGlance]. <br>
<table><tr><td colspan='2'>[[5m7u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M7U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M7U FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XHA:2-[(2~{R},3~{S},4~{R},5~{R})-5-(HYDROXYMETHYL)-3,4-BIS(OXIDANYL)-1-[3-[3-(TRIFLUOROMETHYL)PHENYL]PROPYL]PYRROLIDIN-2-YL]-~{N}-METHYL-ETHANAMIDE'>XHA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MGEA5, HEXC, KIAA0679, MEA5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XHA:2-[(2~{R},3~{S},4~{R},5~{R})-5-(HYDROXYMETHYL)-3,4-BIS(OXIDANYL)-1-[3-[3-(TRIFLUOROMETHYL)PHENYL]PROPYL]PYRROLIDIN-2-YL]-~{N}-METHYL-ETHANAMIDE'>XHA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5m7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m7u OCA], [http://pdbe.org/5m7u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m7u RCSB], [http://www.ebi.ac.uk/pdbsum/5m7u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m7u ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m7u OCA], [https://pdbe.org/5m7u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m7u RCSB], [https://www.ebi.ac.uk/pdbsum/5m7u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m7u ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/OGA_HUMAN OGA_HUMAN]] Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).<ref>PMID:11148210</ref> <ref>PMID:11788610</ref> <ref>PMID:20673219</ref> <ref>PMID:22365600</ref> <ref>PMID:24088714</ref>  Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.<ref>PMID:20673219</ref>
[https://www.uniprot.org/uniprot/OGA_HUMAN OGA_HUMAN] Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).<ref>PMID:11148210</ref> <ref>PMID:11788610</ref> <ref>PMID:20673219</ref> <ref>PMID:22365600</ref> <ref>PMID:24088714</ref>  Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.<ref>PMID:20673219</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5m7u" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5m7u" style="background-color:#fffaf0;"></div>
==See Also==
*[[O-GlcNAcase|O-GlcNAcase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Britton, R]]
[[Category: Britton R]]
[[Category: Chan, S]]
[[Category: Chan S]]
[[Category: Davies, G J]]
[[Category: Davies GJ]]
[[Category: Hemsworth, G R]]
[[Category: Hemsworth GR]]
[[Category: King, D]]
[[Category: King D]]
[[Category: Offen, W A]]
[[Category: Offen WA]]
[[Category: Roth, C]]
[[Category: Roth C]]
[[Category: Varghese, V]]
[[Category: Varghese V]]
[[Category: Vocadlo, D J]]
[[Category: Vocadlo DJ]]
[[Category: Willems, L I]]
[[Category: Willems LI]]
[[Category: Glcnac]]
[[Category: Human glycoside hydrolase]]
[[Category: Hydrolase]]
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