5mun: Difference between revisions

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<StructureSection load='5mun' size='340' side='right'caption='[[5mun]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='5mun' size='340' side='right'caption='[[5mun]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5mun]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MUN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5MUN FirstGlance]. <br>
<table><tr><td colspan='2'>[[5mun]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Porphyromonas_gingivalis Porphyromonas gingivalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MUN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Gingipain_K Gingipain K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.47 3.4.22.47] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5mun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mun OCA], [http://pdbe.org/5mun PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mun RCSB], [http://www.ebi.ac.uk/pdbsum/5mun PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mun ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mun OCA], [https://pdbe.org/5mun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mun RCSB], [https://www.ebi.ac.uk/pdbsum/5mun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mun ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KGP83_PORGN KGP83_PORGN]] Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria (By similarity).[UniProtKB:B2RLK2]  
[https://www.uniprot.org/uniprot/KGP83_PORGN KGP83_PORGN] Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria (By similarity).[UniProtKB:B2RLK2]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Proteinase|Proteinase]]
*[[Proteinase 3D structures|Proteinase 3D structures]]
*[[Proteinase 3D structures|Proteinase 3D structures]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Gingipain K]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Gomis-Ruth, F X]]
[[Category: Porphyromonas gingivalis]]
[[Category: Goulas, T]]
[[Category: Gomis-Ruth FX]]
[[Category: Guevara, T]]
[[Category: Goulas T]]
[[Category: Huntington, J A]]
[[Category: Guevara T]]
[[Category: Mizgalska, D]]
[[Category: Huntington JA]]
[[Category: Nowak, M]]
[[Category: Mizgalska D]]
[[Category: Nowakovska, Z]]
[[Category: Nowak M]]
[[Category: Pomowski, A]]
[[Category: Nowakovska Z]]
[[Category: Potempa, B]]
[[Category: Pomowski A]]
[[Category: Potempa, J]]
[[Category: Potempa B]]
[[Category: Sztukowska, M N]]
[[Category: Potempa J]]
[[Category: Uson, I]]
[[Category: Sztukowska MN]]
[[Category: Veillard, F]]
[[Category: Uson I]]
[[Category: Cysteine protease]]
[[Category: Veillard F]]
[[Category: Hydrolase]]
[[Category: Zymogenic latency]]
Retrieved from "https://proteopedia.org/5mun"