6jmp: Difference between revisions
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==Crystal Structure of a Non-hemolytic Pneumolysin from Streptococcus pneumoniae strain ST306== | ==Crystal Structure of a Non-hemolytic Pneumolysin from Streptococcus pneumoniae strain ST306== | ||
<StructureSection load='6jmp' size='340' side='right'caption='[[6jmp]]' scene=''> | <StructureSection load='6jmp' size='340' side='right'caption='[[6jmp]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JMP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6JMP FirstGlance]. <br> | <table><tr><td colspan='2'>[[6jmp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JMP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6JMP FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6jmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jmp OCA], [http://pdbe.org/6jmp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jmp RCSB], [http://www.ebi.ac.uk/pdbsum/6jmp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jmp ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ply ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6jmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jmp OCA], [http://pdbe.org/6jmp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jmp RCSB], [http://www.ebi.ac.uk/pdbsum/6jmp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jmp ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/Q2XU25_STREE Q2XU25_STREE]] A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation.[RuleBase:RU364025] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Badgujar | [[Category: Badgujar, D C]] | ||
[[Category: Bhaumik P]] | [[Category: Bhaumik, P]] | ||
[[Category: Cholesterol dependent cytolysin]] | |||
[[Category: Membrane]] | |||
[[Category: Non-hemolytic]] | |||
[[Category: Non-pore forming]] | |||
[[Category: Pneumolysin]] | |||
[[Category: Toxin]] | |||
