4l7u: Difference between revisions

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<StructureSection load='4l7u' size='340' side='right'caption='[[4l7u]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='4l7u' size='340' side='right'caption='[[4l7u]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4l7u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7U OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4L7U FirstGlance]. <br>
<table><tr><td colspan='2'>[[4l7u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L7U FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1VC:METHYL+N-[3-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)PROPANOYL]-L-PHENYLALANINATE'>1VC</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1VC:METHYL+N-[3-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)PROPANOYL]-L-PHENYLALANINATE'>1VC</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l6z|4l6z]], [[4l70|4l70]], [[4l7l|4l7l]], [[4l7n|4l7n]], [[4l7o|4l7o]], [[4l7p|4l7p]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7u OCA], [https://pdbe.org/4l7u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l7u RCSB], [https://www.ebi.ac.uk/pdbsum/4l7u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l7u ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADPRT3, ADPRTL3, PARP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4l7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7u OCA], [http://pdbe.org/4l7u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l7u RCSB], [http://www.ebi.ac.uk/pdbsum/4l7u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l7u ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>
[https://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Andersson, C D]]
[[Category: Andersson CD]]
[[Category: Ekblad, T]]
[[Category: Ekblad T]]
[[Category: Elofsson, M]]
[[Category: Elofsson M]]
[[Category: Karlberg, T]]
[[Category: Karlberg T]]
[[Category: Lindgren, A E.G]]
[[Category: Lindgren AEG]]
[[Category: Linusson, A]]
[[Category: Linusson A]]
[[Category: Schuler, H]]
[[Category: Schuler H]]
[[Category: Spjut, S]]
[[Category: Spjut S]]
[[Category: Thorsell, A G]]
[[Category: Thorsell AG]]
[[Category: Weigelt, J]]
[[Category: Weigelt J]]
[[Category: Adp-ribosylation]]
[[Category: Diphtheria toxin like adp-ribose transferase]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/4l7u"