Sandbox GGC1: Difference between revisions

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'''Histone ~~H3.2~~'''

'''Histone chaperone ASF1A'''

This is a default text for your page '''Sandbox GGC1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.

You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

[https://www.uniprot.org/uniprot/~~Q71DI3 Core component of nucleosome~~]. ~~Nucleosomes wrap~~ and ~~compact DNA into~~ chromatin~~, limiting DNA accessibility~~ to ~~the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA~~ replication and ~~chromosomal stability~~. ~~DNA accessibility is regulated via a complex set~~ of ~~post~~-~~translational modifications of histones, also called histone code,~~ and ~~nucleosome remodeling.~~

[https://www.uniprot.org/uniprot/Q9Y294]. Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit

== Disease ==

Sandbox GGC1: Difference between revisions

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-'''Histone H3.2'''
+'''Histone chaperone ASF1A'''
-<StructureSection load='6ATF' size='340' side='right' caption='Caption for this structure' scene=''>
+<StructureSection load='ASF1A' size='340' side='right' caption='Caption for this structure' scene=''>
 This is a default text for your page '''Sandbox GGC1'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
 You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
 == Function ==
-[https://www.uniprot.org/uniprot/Q71DI3 Core component of nucleosome]. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
+[https://www.uniprot.org/uniprot/Q9Y294]. Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit
 == Disease ==